Biochemistry case studies

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Biochemistry case studies

Several members of each recepetor sub-family are indicated below each representative. The Roman numerals above the first seven sub-types correspond to those sub-types described in the Table above.

Many receptors that have intrinsic tyrosine kinase activity as well as the tyrosine kinases that are associated with cell surface receptors contain tyrosine residues, that upon phosphorylation, interact with other proteins of the signaling cascade.

These other proteins contain a domain of amino acid sequences that are homologous to a domain first identified in the SRC proto-oncogene. The typical SH2 domain is approximately amino acids in length. Different SH2 domains recognize different tyrosine phosphorylated residues based upon the presence of the tyrosine phosphate as well as the amino acid sequences surrounding the tyrosine residue.

These variable domains are, therefore, what determine the specificity of SH2 domain-containing protein binding. At least different proteins are expressed in humans that contain SH2 domains.


Another conserved protein-protein interaction domain identified in many signal transduction proteins is related to a third domain in SRC identified as the SH3 domain. Typical SH3 domains are composed of approximately 60 amino acid residues. The interactions of SH2 domain-containing proteins with RTKs or receptor associated tyrosine kinases leads to tyrosine phosphorylation of the SH2 containing proteins.

The result of the phosphorylation of SH2 containing proteins that have enzymatic activity is an alteration either positively or negatively in that activity. There is now recognized two distinct families of non-receptor PTKs. The SRC protein is a tyrosine kinase first identified as the transforming protein in Rous sarcoma virus.

Medical Reports and Case Studies- Open Access Journals

Subsequently, a cellular homolog was identified. Numerous proto-oncogenes were identified as the transforming proteins carried by retroviruses. The second family is related to the Janus kinase JAK. Most of the proteins of both families of non-receptor PTKs couple to cellular receptors that lack enzymatic activity themselves.

This class of receptors includes all of the cytokine receptors e. Another example of receptor-signaling through protein interaction involves the insulin receptor IR.

Biochemistry case studies

This receptor has intrinsic tyrosine kinase activity but does not directly interact, following autophosphorylation, with enzymatically active proteins containing SH2 domains e.

Additional adapter proteins have been identified, the most commonly occurring being a protein termed growth factor receptor-binding protein 2, GRB2. An example of an alteration in receptor activity in response to association with an intracellular PTK is the nicotinic acetylcholine receptor AChR.

These receptors comprise an ion channel consisting of five distinct subunits alpha: At least 12 RSKs have been characterized as being expressed in humans.

These receptors can be divided into two subfamilies identified as the type I and type II receptors. Ligands first bind to the type II receptors which then leads to interaction with the type I receptors. The type II protein phosphorylates the kinase domain of the type I partner leading to displacement of proteins called subunit or protein partners.

The displacement of these protein partners allows for the binding and phosphorylation of particular members of the Smad family. Once phosphorylated, the particular Smad will migrate to the nucleus and act as complexes that regulate the expression of specific target genes.Patient: A year-old female presented to the Emergency Department with fever, abdominal pain and vomiting.

The patient has a background history of left breast carcinoma with metastasis to the lung, bone and liver.

Biochemistry case studies

She underwent surgery, chemotherapy and radiotherapy. Medical Reports & Case Studies (MRCS) is a peer-reviewed online open access journal which publishes original research work and case reports in all areas of clinical, medical & life sciences, which are not limited to diseases, symptoms, signs, diagnosis, treatment, new findings, techniques, outcomes of researches..

The journal is established to create a platform for researchers, practitioners. Dean R. Appling is the Lester J. Reed Professor of Biochemistry and the Associate Dean for Research and Facilities for the College of Natural Sciences at the University of Texas at Austin, where he has taught and done research for the past 29 years.

Dean earned his B.S. in Biology from Texas A&M University () and his Ph.D. in Biochemistry from Vanderbilt University (). Fatty Acids.

Fatty acids fill three major roles in the body: 1. as the components of more complex membrane lipids. 2. as the major components of stored fat in the form of triglycerides. 3. as the precursors for the synthesis of bioactive lipids.

Fatty acids are long-chain hydrocarbon molecules containing a carboxylic acid moiety at one end. This clicker case introduces students to the biochemistry of lipids through the story of Pete, a college student who begins to consider his nutritional fat intake after watching a commercial for the cholesterol-lowering drug Vytorin.

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Case Studies | Biochemistry for Medics – Lecture Notes